AEP REGISTER

Australian Pregnancy Register                                                             Please call us: 1800 069 722

Australian Pregnancy Register for Women on Antiepileptic Medication with Epilepsy and Allied Conditions
ABN: 38 128 668 797 

This is a voluntary, nationwide study that is enrolling women who are currently pregnant or who have given birth recently (infants up to 12 months of age) in the following categories: 
  • Women with epilepsy taking antiepileptic medication (AEDs).
  • Women with epilepsy not taking AEDs. 
  • Women taking AEDs for allied conditions.

The program needs a significant boost to the number of women participating in the study, as well as increasing the length of the study, to ensure enough evidence is collected for the findings to become treatment guidelines.

Background

From previous research it is known that women who are taking an AED may have a slightly higher incidence (4-6%) of having babies with birth defects than the general population (2-3%).

The Australian Pregnancy Register (APR) is an independent project that has been running for over 16 years nationally. We are an observational register and collect information about pregnant women with epilepsy, treated and untreated, to determine which AEDs are safest for the baby while protecting the mother from seizures.

Information from pregnancy registers is a valuable resource for the study of comparative risks and benefits of antiepileptic drugs in pregnancy.  As a result of this study we are getting closer to defining safer treatment choices. 

Epilepsy Action Australia recently formed a major partnership with the Australian Pregnancy Register to enable the research to continue and increase the number of women registered. The aim is to increase the number from 2,500 to 5,000 women in 3 years.

The aims of this project are

  • To evaluate the incidence of adverse foetal outcomes resulting from pregnancies exposed to antiepileptic drugs (AEDs)
  • To determine if certain AEDs or combinations are associated with a higher incidence or specific types of adverse pregnancy outcomes.
  • To determine the influence of the seizures, the epilepsy type, the genetic background and environmental factors.
  • To study the comparative efficacy of AEDs on seizure protection in pregnancy, assessed on the basis of self reporting and increased dose or additional drug requirements.

DO NOT STOP MEDICATIONS WITHOUT FIRST CONSULTING YOUR DOCTOR AS THIS MAY RESULT IN UNCONTROLLED SEIZURES WITH POTENTIALLY SERIOUS CONSEQUENCES FOR BOTH THE MOTHER AND THE UNBORN BABY. 

If you would like more information about the study or to register please call us on 1800 069 722 or register below. 

Register Now

Advisory Board

Frank Vajda
Director & Principal Investigator 
Prof Frank Vajda AM

Principal Investigator 
A/Prof Cecilie Lander

Co Investigator 
Prof Terry O'Brien 

Research Coordinators
Janet Graham
Alison Hitchcock
Treasurer 
Peter Davis

Advisory Board Members 
Sam Berkovic, Andrew Bleasel, John Dunne, Wendyl D'Souza, Mervyn Eadie, Geoff Herkes,  Michelle Kiley, Raphael Kuhn,  Patrick Kwan, Dan McLaughlin, Jim Pelekanos,  Piero Peruca, Ernie Somerville and Liz Walker

research sponsors

Major Financial Supporter
Epilepsy Action Australia

Epilepsy Australia
Epilepsy Society of Australia
Eisai
Janssen Cilag
NHMRC
Novartis
RMH Neuroscience Foundation
Sanofi Aventis
SciGen
UCB Pharma

information documents

Enrolment



Journal Articles - for more information, click the link for a list of further reading material by the Australian Epilepsy Register
Share by: